Spivak N Ia, Grabchenko N I, Lazarenko L N, Tovt-Korshinskaia M I, Ganova L A, Timoshok N A, Krivokhatskaia L D, Mikhaĭlenko O N, Karpov A V, Mikhaĭlenko T I, Zotsenko V N
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
Mikrobiol Z. 1999 Jan-Feb;61(1):32-45.
Experimental data have been presented which prove antibacterial efficiency of interferon preparations and inducers under infection processes evoked by Staphylococcus aureus, Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae. It is shown that the system of phagocytizing cells and natural cells-killers plays the basic protective role in the organism under the persistence of these microbes. The basic regularities of activating effect of interferon preparations and its inducers on the functional activity of the above mentioned cells have been found. The methods of treatment with interferon drugs based on experimental data have been developed for the first time. They were used to cure patients with pyo-septic diseases.
已经提供了实验数据，这些数据证明了在由金黄色葡萄球菌、鼠伤寒沙门氏菌、铜绿假单胞菌、肺炎克雷伯菌引起的感染过程中，干扰素制剂和诱导剂的抗菌效果。结果表明，在这些微生物持续存在的情况下，吞噬细胞和天然细胞杀手系统在机体中发挥着基本的保护作用。已经发现了干扰素制剂及其诱导剂对上述细胞功能活性的激活作用的基本规律。首次根据实验数据开发了用干扰素药物治疗的方法。这些方法被用于治疗脓毒症患者。
