Fil'chakov I V, Fil'chakov F V, Ivanenko V K, Blagodatnyĭ V N, Blizniuk I A
Mikrobiol Z. 1993 Nov-Dec;55(6):57-62.
Homologous interferons (IF) of the 1st and 2nd types are studied for their effect on the course of experimental staphylococcal infection. A model of intracutaneous infection of animals is used. Survival of mice, dynamics of the agent elimination from the organism, functional activity of phagocytes in dynamics of the infectious process during IF administration are studied. Only preparations of natural IF are found to possess a protective effect. The recombinant gamma-IF does not prevents from the mouse death and exerts no effect on the dynamics of elimination of agents from the organism.
研究了第一类和第二类同源干扰素对实验性葡萄球菌感染病程的影响。采用动物皮内感染模型。研究了小鼠的存活率、病原体从机体清除的动态过程、在给予干扰素期间感染过程中吞噬细胞的功能活性动态。结果发现，只有天然干扰素制剂具有保护作用。重组γ干扰素不能防止小鼠死亡，对病原体从机体清除的动态过程也没有影响。
