先天性心脏病手术后学龄前儿童发育的对照研究。
Controlled study of preschool development after surgery for congenital heart disease.
作者信息
Wray J, Sensky T
机构信息
Paediatric Surgical Unit, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK.
出版信息
Arch Dis Child. 1999 Jun;80(6):511-6. doi: 10.1136/adc.80.6.511.
AIM
Research into intellectual impairment among children with congenital heart disease has focused mainly on older children. This study was designed to determine whether previous findings are applicable to preschool children.
METHODS
Three groups of children under 31/2 years old were assessed immediately before treatment and 12 months later: a group with congenital heart disease awaiting surgery, another awaiting bone marrow transplantation, and a healthy comparison group.
RESULTS
Although the means of the three groups were within the normal range, preoperatively the cardiac and transplant groups showed deficits compared with the healthy controls. Postoperatively, continuing developmental deficits were significant only in the children with cyanotic lesions.
CONCLUSIONS
Conclusions about intellectual development in older children with congenital heart disease do not apply to preschool children. Before corrective surgery, chronic illness itself appears to be the predominant influence on development. Postoperatively, cyanotic and acyanotic lesions are associated with different short term outcomes.
目的
对先天性心脏病患儿智力损害的研究主要集中在大龄儿童。本研究旨在确定先前的研究结果是否适用于学龄前儿童。
方法
对三组3岁半以下的儿童在治疗前及12个月后进行评估：一组为等待手术的先天性心脏病患儿，另一组为等待骨髓移植的患儿，还有一个健康对照组。
结果
虽然三组的均值在正常范围内，但术前心脏疾病组和移植组与健康对照组相比存在缺陷。术后，持续的发育缺陷仅在患有青紫型病变的儿童中显著。
结论
关于大龄先天性心脏病患儿智力发育的结论不适用于学龄前儿童。在矫正手术前，慢性病本身似乎是对发育的主要影响因素。术后，青紫型和非青紫型病变与不同的短期结果相关。
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