Merino G, Alvarez A I, Redondo P A, Garcia J L, Larrodé O M, Prieto J G
Laboratory of Animal Physiology. Faculty of Veterinary., University of León, León, E24071, Spain.
Res Vet Sci. 1999 Jun;66(3):281-3. doi: 10.1053/rvsc.1998.0276.
After oral co-administration of two dosages of netobimin (7.5 and 20 mg kg-1 with fenbendazole (1.1 mg kg-1) to Merino sheep, the AUC0-infinity of albendazole sulphoxide at the lower dosage of netobimin, was significantly increased (75.5 per cent) from control value (34.43 +/- 7.91 versus 60.33 +/- 11.93 microg h ml-1). The pharmacokinetic parameters MRT and T1/2 were also increased: 18.96 +/- 2.54 vs 26.44 +/- 4.69 h and 10.31 +/- 1.72 vs 22.28 +/- 6.75 h respectively. No data corresponding to the higher dosage of netobimin (20 mg kg-1) were statistically different from control values. It is concluded that fenbendazole increases the bioavailability of albendazole sulphoxide in sheep at the 7.5 mg kg-1 dosage, and this may produce a potentiated anthelmintic action.
对美利奴羊口服两种剂量的奈托比明（7.5和20毫克/千克）与芬苯达唑（1.1毫克/千克）共同给药后，奈托比明较低剂量时阿苯达唑亚砜的AUC0-无穷大较对照值显著增加（75.5%）（34.43±7.91对60.33±11.93微克·小时/毫升）。药代动力学参数平均滞留时间（MRT）和半衰期（T1/2）也增加：分别为18.96±2.54对26.44±4.69小时以及10.31±1.72对22.28±6.75小时。与奈托比明较高剂量（20毫克/千克）对应的数据与对照值无统计学差异。结论是，芬苯达唑在7.5毫克/千克剂量时可提高绵羊体内阿苯达唑亚砜的生物利用度，这可能产生增强的驱虫作用。
