Effect of prostacyclin on gastric mucosal RNA-content in the rat.

We investigated changes in gastric (antral and fundic) mucosal RNA contents in single-dose and in long-term (10 weeks) treatment of rats with receiving oral graded doses of prostacyclin. Long-term application of prostacyclin evoked no significant changes, while in the single-dose experiments there was a dose-dependent elevation in RNA-content in both parts of the gastric mucosa. The results are interpreted as convincing signs of the gastro-protective effect of prostacyclin.