长期使用前列环素治疗对大鼠胃（胃窦和胃底）黏膜的DNA和RNA含量有剂量依赖性作用。
Long-term prostacyclin--treatment acts on the DNA and RNA content of rat gastric (antral and fundic) mucosa dose-dependently.
作者信息
Bálint G A, Karácsony G
机构信息
Dept. of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
出版信息
Acta Med Hung. 1992;49(1-2):137-41.
The changes in gastric (antral and fundic) mucosal DNA and RNA contents were investigated in long-term (80 days) treatment of rats with orally administered prostacyclin. Prostacyclin caused a dose-dependent, significant increase of the DNA levels in both parts of the gastric mucosa together with a significant thickening of the fundic mucosa. The observed changes (decrease) of the RNA/DNA ratio in the fundic as well as antral mucosa, are interpreted as a sign of accelerated cell renewal, i.e. hyperplasia.
在对大鼠进行长期（80天）口服前列环素治疗的过程中，研究了胃（胃窦和胃底）黏膜DNA和RNA含量的变化。前列环素导致胃黏膜两部分的DNA水平呈剂量依赖性显著增加，同时胃底黏膜显著增厚。在胃底和胃窦黏膜中观察到的RNA/DNA比值变化（降低），被解释为细胞更新加速即增生的迹象。
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