Vaziri N D, Ateshkadi A
Department of Medicine, University of California, Irvine 92868, USA.
Nephrol Dial Transplant. 1999;14 Suppl 2:46-9. doi: 10.1093/ndt/14.suppl_2.46.
In addition to promoting erythropoiesis, chronic administration of epoetin frequently increases blood pressure, ameliorates uraemic platelet dysfunction, enhances platelet production and elevates resting and stimulated cytosolic [Ca2+]. In addition, in vivo and in vitro studies have demonstrated that epoetin may modify production and activity of certain vasoactive factors and may promote vascular cell growth. Many of the latter effects of epoetin appear to be unrelated to the associated erythropoietic action of the hormone and must, therefore, involve other mechanisms. The present article is intended to provide a brief overview of the effects of epoetin on vascular and haemostatic systems.
除了促进红细胞生成外，长期使用促红细胞生成素通常会升高血压，改善尿毒症血小板功能障碍，增强血小板生成并提高静息和刺激状态下的胞质[Ca2+]浓度。此外，体内和体外研究表明，促红细胞生成素可能会改变某些血管活性因子的产生和活性，并可能促进血管细胞生长。促红细胞生成素的许多后一种作用似乎与该激素相关的促红细胞生成作用无关，因此必定涉及其他机制。本文旨在简要概述促红细胞生成素对血管和止血系统的影响。
