Tsuyumu M, Suganuma Y, Ohata M, Hiratsuka H, Inaba Y
No Shinkei Geka. 1976 Oct;4(10):947-51.
Despite vast improvement in diagnostic techniques in neurosurgery during the past few decades, there still remain a significant number of intracranial tumors in geriatric age group, which are not recognized in the early course of the disease or during life. We are now focusing on the diagnostic problems of meningiomas in the geriatric age group and stressing the significant value of brain scanning in the differential diagnosis of brain tumors from cerebral vascular disease or other conditions. During about 10-year period, a total of 36 intracranial tumours in cases over 60 year old have been studied. Sixteen of these tumors are meningiomas and form the basis of this report. The age of these cases was between 60 and 83 years with average of 70.5. There were two males and 14 females. As to the location, four were parsagittal and falx meningiomas, three were at tuberculum sellae, two were at sphenoidal ridge, one was at tentorium in location. Twelve cases were erroniously diagnosed and confusion with cerebrovascular disease was most common. We analysed the onset and the progression of symptoms of our 16 cases, and picked up and stressed the four peculiarities of geriatric meningiomas. The first one is that the onset of symptoms is very sudden, almost precipitate, and the subsequent clinical course may be so rapidly progressive. The six patients in our cases were included in this group. A case among those was verified to be complicated with intratumoral hemorrhage, and another one with a subdural hematoma. The vast contrast to the first group is the second peculiarity. The meningioma especially in the geriatric age group may frequently unfold a clinical picture, which by its very insidious onset and slow development may be even unrecognized during life. The third is that patients developed dementia, at the onset in two cases and in any course of this disease in six. All too frequently in these instances the tumor has been overlooked and wrongly diagnosed as a senile dementia or psychosis. The fourth is that the meningioma developed with intermittent, recurrent and streotyped cerebral symptoms including epilepsy. We presented a case with intermittent aphasia due to a convexity meningioma on the dominant side. In almost all cases, manifestation of increased intracranial pressure was absent or not significant. There was found a papilledema in only one case, and cerebrospinal fluid revealed a normal pressure in six out of eight cases in which lumbar puncture was performed. It was proved that brain scanning was one of the most useful adjuncts in the diagnosis of brain tumor in the aged even in serious conditions. Changing brain scan patterns in association with clinical course is a useful diagnostic guide in differentiating tumors from cerebrovascular accidents. The serial scan density change is more meaningful if the clinical course is considered. Scanning should be done as soon as possible when the brain tumor is suspected and should be rescanned if necessary.
尽管在过去几十年中神经外科诊断技术有了巨大进步,但老年人群中仍有相当数量的颅内肿瘤在疾病早期或生前未被发现。我们目前关注老年人群中脑膜瘤的诊断问题,并强调脑部扫描在鉴别脑肿瘤与脑血管疾病或其他病症方面的重要价值。在大约10年的时间里,我们共研究了60岁以上患者的36例颅内肿瘤。其中16例为脑膜瘤,构成了本报告的基础。这些病例的年龄在60至83岁之间,平均年龄为70.5岁。男性2例,女性14例。就位置而言,4例为矢状窦旁和镰旁脑膜瘤,3例位于鞍结节,2例位于蝶骨嵴,1例位于小脑幕。12例被误诊,最常见的是与脑血管疾病混淆。我们分析了16例患者的症状发作和进展情况,找出并强调了老年脑膜瘤的四个特点。第一个特点是症状发作非常突然,几乎是急骤的,随后的临床病程可能进展迅速。我们的病例中有6例属于这一组。其中1例被证实合并肿瘤内出血,另一例合并硬膜下血肿。与第一组形成巨大反差的是第二个特点。脑膜瘤尤其是在老年人群中,可能经常呈现出一种临床症状,其起病隐匿、发展缓慢,甚至在生前可能未被察觉。第三个特点是患者出现痴呆,2例在起病时出现,6例在疾病的任何阶段出现。在这些情况下,肿瘤常常被忽视,并被错误地诊断为老年性痴呆或精神病。第四个特点是脑膜瘤伴有间歇性、反复发作和刻板的脑部症状,包括癫痫。我们报告了1例因优势侧凸面脑膜瘤导致间歇性失语的病例。几乎所有病例中,颅内压升高的表现不存在或不明显。仅1例发现视乳头水肿,在进行腰椎穿刺的8例病例中,6例脑脊液压力正常。事实证明,即使在病情严重的情况下,脑部扫描也是老年脑肿瘤诊断中最有用的辅助手段之一。结合临床病程的脑部扫描模式变化是鉴别肿瘤与脑血管意外的有用诊断指南。如果考虑临床病程,系列扫描密度变化更有意义。当怀疑有脑肿瘤时应尽快进行扫描,必要时应再次扫描。