Gelabert-González M, Leira-Muiño R, Fernández-Villa J M, Iglesias-Pais M
Servicio de Neurocirugía, Hospital Clínico Universitario de Santiago, Departamento de Cirugía, Universidad de Santiago de Compostela, Santiago de Compostela, España.
Rev Neurol. 2003;37(8):717-22.
Multiple meningiomas is a condition in which the patient had more than one meningioma in several intracranial locations in the same patient without signs of neurofibromatosis. The incidence of multiple intracranial meningiomas varies from 1 to 10% in different series. In this article we report our experience with the diagnosis and treatment of multiple meningioma.
The authors report 13 cases of multiple intracranial meningioma, consecutively operated on at our hospital between 1983-2003. All the patients were studied with CT and the last 10 with MRI. In 8 patients all of the tumours were found at the first admission. In the other five the diagnosis was not established until years after removal of the first meningioma. All the patients showed no manifestations of von Recklinghausen disease.
The overall average age at diagnosis was 53.3 years: 7 were females and 6 males. The predominant site for the meningioma was the parasagittal and falcine region, followed by the cerebral convexity. Thirty-two meningiomas were treated with surgical extirpation and in four cases the treatment was radiotherapy.
Multiple meningiomas are not a specific disease entity and have no distinctive clinical, pathological or surgical features. Despite the multiplicity of sites, multiple meningiomas do not differ in prognosis from benign solitary meningiomas.
多发性脑膜瘤是指患者在颅内多个部位有不止一个脑膜瘤,且无神经纤维瘤病体征的一种病症。在不同系列研究中,颅内多发性脑膜瘤的发病率在1%至10%之间。在本文中,我们报告我们对多发性脑膜瘤的诊断和治疗经验。
作者报告了13例颅内多发性脑膜瘤病例,这些病例于1983年至2003年在我院连续接受手术治疗。所有患者均接受了CT检查,最后10例还接受了MRI检查。8例患者在首次入院时就发现了所有肿瘤。另外5例患者直到切除首个脑膜瘤数年之后才确诊。所有患者均无冯·雷克林豪森病的表现。
诊断时的总体平均年龄为53.3岁:7例为女性,6例为男性。脑膜瘤的主要部位是矢状窦旁和大脑镰区域,其次是脑凸面。32个脑膜瘤接受了手术切除治疗,4例接受了放射治疗。
多发性脑膜瘤不是一种特定的疾病实体,没有独特的临床、病理或手术特征。尽管肿瘤部位多样,但多发性脑膜瘤的预后与良性孤立性脑膜瘤并无差异。