Kopczyński J, Janeczko D, Lewandowski Z, Janeczko-Sosnowska E, Tuszyńska A, Czyzyk A
Zakład Epidemiologii Instytutu Medycyny Społecznej Akademii Medycznej w Warszawie.
Pol Arch Med Wewn. 1998 Sep;100(3):236-44.
From the follow-up examination of 1329 out of 4420 type 2 (non-insulin-dependent) diabetes followed for 17 years, the incidence of micro and macrovascular complications (proteinuria and nephropathy, symptoms of leg vascular disease, ischemic heart disease, and cerebrovascular events, was estimated and related to the levels of baseline-risk variables using logistic regression. For new cases of proteinuria and heavy proteinuria, hyperglycemia was the common predictor (alongside diastolic hypertension, smoking and overweight); hyperglycemia and glycosuria were among significant predictors of leg vascular disease (with duration of diabetes, smoking, male sex, diastolic hypertension, and proteinuria). On the other hand, systolic hypertension and male sex prevailed among factors predicting both ischemic heart disease (with high cholesterol and overweight), and stroke. The data confirm the higher involvement of diabetic milieu in micro than macrovascular incidents, with diabetic foot disease placed in between.
在对4420例2型(非胰岛素依赖型)糖尿病患者进行17年随访的1329例患者的后续检查中,通过逻辑回归估计了微血管和大血管并发症(蛋白尿和肾病、腿部血管疾病症状、缺血性心脏病和脑血管事件)的发生率,并将其与基线风险变量水平相关联。对于蛋白尿和大量蛋白尿的新病例,高血糖是常见的预测因素(与舒张压高血压、吸烟和超重一起);高血糖和糖尿是腿部血管疾病的重要预测因素(与糖尿病病程、吸烟、男性、舒张压高血压和蛋白尿一起)。另一方面,收缩压高血压和男性在预测缺血性心脏病(与高胆固醇和超重一起)和中风的因素中占主导地位。数据证实,糖尿病环境在微血管事件中的参与程度高于大血管事件,糖尿病足病则介于两者之间。