Björklund M, Sirviö J, Sallinen J, Scheinin M, Kobilka B K, Riekkinen P
Department of Neurology and Neuroscience, University of Kuopio, Finland.
Neuroscience. 1999;88(4):1187-98. doi: 10.1016/s0306-4522(98)00306-6.
We investigated the role of alpha2C-adrenoceptors in the modulation of spatial and non-spatial navigation behaviour. Alpha2C-adrenoceptor overexpressing mice developed an ineffective thigmotaxic search pattern characterized by swimming close to the pool walls during both spatial and non-spatial water maze training. A subtype-non-selective alpha2-adrenoceptor antagonist, atipamezole (1000 microg/kg, s.c.), fully reversed this impairment in their search strategy. Withdrawal of atipamezole at the end of spatial training resulted in an immediate disruption of the search pattern in alpha2C-adrenoceptor overexpressing mice. The swimming pattern of alpha2C-adrenoceptor overexpressing mice during a five day free swimming period was normal, when no cognitive component was required. Diazepam (0.3 and 1.0 mg/kg, i.p.), neither improved the accuracy in finding the platform nor decreased thigmotaxis. These results suggest that alpha2C-adrenoceptors may modulate the execution of complex navigation patterns.
我们研究了α2C-肾上腺素能受体在调节空间和非空间导航行为中的作用。过表达α2C-肾上腺素能受体的小鼠形成了一种无效的趋触性搜索模式，其特征是在空间和非空间水迷宫训练期间靠近池壁游动。一种非亚型选择性α2-肾上腺素能受体拮抗剂阿替美唑（1000微克/千克，皮下注射）完全逆转了它们搜索策略中的这种缺陷。在空间训练结束时停用阿替美唑会导致过表达α2C-肾上腺素能受体的小鼠的搜索模式立即中断。在不需要认知成分的五天自由游泳期间，过表达α2C-肾上腺素能受体的小鼠的游泳模式正常。地西泮（0.3和1.0毫克/千克，腹腔注射）既没有提高找到平台的准确性，也没有减少趋触性。这些结果表明，α2C-肾上腺素能受体可能调节复杂导航模式的执行。
