Haapalinna A, Sirviö J, Lammintausta R
Orion, Orion Pharma, Preclinical R&D, Turku, Finland.
Eur J Pharmacol. 1998 Apr 17;347(1):29-40. doi: 10.1016/s0014-2999(98)00077-6.
The present experiments investigated the effects of a specific and potent alpha2-adrenoceptor antagonist, atipamezole (as a stimulator of the noradrenergic system) on cognitive performance in rats. Atipamezole enhanced the acquisition of a linear-arm maze test and also improved the choice accuracy of poorly performing rats in a delayed (20 min) three-choice maze test. Furthermore, atipamezole improved the achievement of a one-trial appetite-maze when injected immediately after teaching, thus having an effect on consolidation. Atipamezole clearly impaired the acquisition of the active avoidance test. The present results indicate that stimulation of noradrenergic system by atipamezole improves the performance of animals in tasks assessing relational learning and memory, possibly affecting attention, short-term memory and the speed of information processing. It has also an effect on a consolidation process unrelated to attentional or motivational mechanisms. In a stressful test. stimulation of noradrenaline release leads to impairment of performance.
本实验研究了一种特异性强效α2-肾上腺素能受体拮抗剂阿替美唑（作为去甲肾上腺素能系统的刺激剂）对大鼠认知能力的影响。阿替美唑增强了直线臂迷宫试验的习得能力，还提高了表现较差的大鼠在延迟（20分钟）三选迷宫试验中的选择准确性。此外，在教学后立即注射阿替美唑可提高一次性食欲迷宫的成绩，从而对巩固产生影响。阿替美唑明显损害了主动回避试验的习得能力。目前的结果表明，阿替美唑刺激去甲肾上腺素能系统可改善动物在评估关系学习和记忆任务中的表现，可能影响注意力、短期记忆和信息处理速度。它对与注意力或动机机制无关的巩固过程也有影响。在应激试验中，去甲肾上腺素释放的刺激会导致表现受损。
