Laitinen M, Hietanen E
Acta Pharmacol Toxicol (Copenh). 1978 Nov;43(5):363-7. doi: 10.1111/j.1600-0773.1978.tb02279.x.
The effect of ingested copper on the composition of duodenal postmitochondrial supernatnat fraction (PMS), the aryl hydrocarbon hydroxylase (AHH) and UDPglucuronosyltransferase (GT) activities was analyzed in rats given normal or fat free diets. There were only minor changes in the composition of PMS or in the activities of the measured enzymes when rats received a normal diet. During fat deficiency the phospholipid-protein ratio and the GT activity were markedly increased following 10 mM copper concentration in the drinking water. It is concluded that during fat deficiency copper modifies the structure of the microsomes, as analyzed in the PMS, and that this is reflected in the membrane bound GT activity.
在给予正常饮食或无脂饮食的大鼠中，分析了摄入铜对十二指肠线粒体后上清液部分（PMS）的组成、芳烃羟化酶（AHH）和尿苷二磷酸葡萄糖醛酸转移酶（GT）活性的影响。当大鼠接受正常饮食时，PMS的组成或所测酶的活性仅有微小变化。在脂肪缺乏期间，饮用水中铜浓度为10 mM时，磷脂 - 蛋白质比率和GT活性显著增加。结论是，在脂肪缺乏期间，铜改变了如在PMS中所分析的微粒体结构，并且这反映在膜结合的GT活性上。
