Kojima K, Nishimura R, Mutoh T, Takao K, Matsunaga S, Mochizuki M, Sasaki N
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan.
Zentralbl Veterinarmed A. 1999 Apr;46(3):141-8. doi: 10.1046/j.1439-0442.1999.00194.x.
Sedative effects of medetomidine at 20 micrograms/kg and midazolam at 0.3 mg/kg (MM), acepromazine at 0.05 mg/kg and butorphanol at 0.2 mg/kg (AB), and midazolam at 0.1 mg/kg and butorphanol at 0.2 mg/kg (MB) were compared in dogs. All dogs given MM were laterally recumbent within 11 min of the administration of the drugs, and this combination also induced deep sedation accompanied by analgesia and muscle relaxation, and strongly depressed arousal reactions to external stimuli. However, undesirable effects such as bradycardia and decreased respiration were also observed in dogs given MM. Six of seven dogs given AB were laterally recumbent within 16 min of the administration of the drugs, and this combination induced relatively deep sedation but only a mild depression of arousal reactions to external stimuli. MB induced mild or moderate sedation with relatively large differences in effects among individuals. The recovery from sedation in each group was smooth and total recovery times were not significantly different.
在犬类中比较了20微克/千克的美托咪定与0.3毫克/千克的咪达唑仑（MM）、0.05毫克/千克的乙酰丙嗪与0.2毫克/千克的布托啡诺（AB）以及0.1毫克/千克的咪达唑仑与0.2毫克/千克的布托啡诺（MB）的镇静效果。所有给予MM的犬在给药后11分钟内呈侧卧姿势，并且这种组合还诱导了深度镇静，伴有镇痛和肌肉松弛，并强烈抑制对外界刺激的觉醒反应。然而，给予MM的犬也观察到了诸如心动过缓和呼吸减慢等不良影响。给予AB的七只犬中有六只在给药后16分钟内呈侧卧姿势，并且这种组合诱导了相对深度的镇静，但仅对外界刺激的觉醒反应有轻度抑制。MB诱导了轻度或中度镇静，个体之间的效果差异相对较大。每组的镇静恢复都很顺利，总恢复时间没有显著差异。
