Magro G, Fraggetta F, Torrisi A, Emmanuele C, Lanzafame S
Istituto di Anatomia Patologica, Università di Catania, Italy.
Pathol Res Pract. 1999;195(4):257-62. doi: 10.1016/S0344-0338(99)80044-2.
Myofibroblastoma (MFB) of the breast is an uncommon benign spindle cell tumor which may exhibit a wide spectrum of histological features. We report an unusual case of MFB of the male breast, showing cellular areas with a hemangiopericytoma-like pattern similar to that observed in solitary fibrous tumor (SFT) and extensive fibromyxoid areas containing numerous atypical stromal cells. The association of these atypical cells with mature adipocytes and microcystic and/or myxoid degenerative changes resembled pleomorphic lipoma-like and myxoid liposarcoma-like features, respectively. To our knowledge, these peculiar morphological findings have not been previously reported in MFB of the breast. They should be recognized to avoid confusion with other mesenchymal tumors, especially with hemangiopericytoma, pleomorphic lipoma (PL), spindle-cell lipoma (SCL) and myxoid liposarcoma. A case of MFB of the breast showing morphological features also commonly seen in SFT and PL/SCL is further morphological evidence in support of the speculation that the mesenchymal tumors of the breast, also known under the terms benign spindle cell tumors, fibromas, SFTs, SCLs and MFBs, are histogenetically related lesions.
乳腺肌成纤维细胞瘤（MFB）是一种罕见的良性梭形细胞肿瘤，其组织学特征可能具有广泛的多样性。我们报告了一例男性乳腺MFB的罕见病例，该病例显示细胞区域具有类似于孤立性纤维瘤（SFT）中观察到的血管外皮细胞瘤样模式，以及含有大量非典型间质细胞的广泛纤维黏液样区域。这些非典型细胞与成熟脂肪细胞的关联以及微囊性和/或黏液样退行性改变分别类似于多形性脂肪瘤样和黏液样脂肪肉瘤样特征。据我们所知，这些特殊的形态学发现此前尚未在乳腺MFB中报道过。应认识到这些发现，以避免与其他间叶性肿瘤混淆，尤其是与血管外皮细胞瘤、多形性脂肪瘤（PL）、梭形细胞脂肪瘤（SCL）和黏液样脂肪肉瘤混淆。一例乳腺MFB表现出在SFT和PL/SCL中也常见的形态学特征，进一步从形态学上支持了以下推测：乳腺的间叶性肿瘤，也被称为良性梭形细胞肿瘤、纤维瘤、SFT、SCL和MFB，是组织发生学上相关的病变。
