增殖细胞核抗原（PCNA）与超急性和急性心肌梗死中的细胞凋亡

Proliferating cell nuclear antigen (PCNA) and apoptosis in hyperacute and acute myocardial infarction.

作者信息

Ottaviani G, Lavezzi A M, Rossi L, Matturri L

机构信息

Institute of Pathology, University of Study of Milan, IRCCS Ospedale Maggiore, Italy.

出版信息

Eur J Histochem. 1999;43(1):7-14.

PMID:10340138

Abstract

The aim of this study was to determine whether cell proliferation and/or apoptotic cell death occur in hyperacute and acute infarction. Proliferating cell nuclear antigen (PCNA) and apoptosis were investigated in ten autoptic hearts within a few hours of infarction and in three normal hearts as controls. The PCNA Labeling Index (PCNA-LI) ranged from 0 to 3.1 in hyperacute infarction (mean 1.38), from 0.3 to 4 in acute infarction (mean 2.04) and from 0 to 1.2 in controls (mean 0.7). Although the results were not statistically significant, PCNA-LI was higher in acute than in hyperacute myocardial infarctions; and it was higher in hyperacute infarctions than in controls. Regarding apoptosis, the Apoptotic Index (AI) in hyperacute infarctions ranged from 0.7 to 3 (mean 1.78), in acute infarctions from 0.9 to 5 (mean 3.24) and in controls from 0 to 0.4 (mean 0.1). The AI was significantly higher in hyperacute and acute infarctions than in controls (p < 0.05).

摘要

本研究的目的是确定在超急性和急性梗死中是否发生细胞增殖和/或凋亡性细胞死亡。在梗死数小时内的10例尸检心脏以及3例正常心脏作为对照中，对增殖细胞核抗原（PCNA）和凋亡进行了研究。在超急性梗死中，PCNA标记指数（PCNA-LI）范围为0至3.1（平均1.38），急性梗死中为0.3至4（平均2.04），对照组中为0至1.2（平均0.7）。尽管结果无统计学意义，但急性心肌梗死中的PCNA-LI高于超急性心肌梗死；超急性梗死中的PCNA-LI高于对照组。关于凋亡，超急性梗死中的凋亡指数（AI）范围为0.7至3（平均1.78），急性梗死中为0.9至5（平均3.24），对照组中为0至0.4（平均0.1）。超急性和急性梗死中的AI显著高于对照组（p<0.05）。