Itou Y, Suzuki S, Ishida K, Murakami M
Laboratory of Marine Biochemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Bioorg Med Chem Lett. 1999 May 3;9(9):1243-6. doi: 10.1016/s0960-894x(99)00191-2.
Anahaenopeptins G (1) and H (2) were isolated from the cultured cyanobacterium Oscillatoria agardhii (NIES-595) as potent carboxypeptidase A (CPA) inhibitors. The gross structure of 1 and 2 were established by spectroscopic analysis including the 2D NMR technique and the absolute configurations of 1 and 2 were determined by the spectral and chemical methods. 1 and 2 inhibited CPA with IC50's of 0.0018 and 3.4 microg/mL, respectively.
从培养的蓝藻颤藻（NIES-595）中分离出了阿那海肽G（1）和H（2），它们是强效的羧肽酶A（CPA）抑制剂。通过包括二维核磁共振技术在内的光谱分析确定了1和2的总体结构，并通过光谱和化学方法确定了1和2的绝对构型。1和2对CPA的抑制IC50分别为0.0018和3.4微克/毫升。
