用于基因递送的二醚连接阳离子脂质的合成。
Synthesis of diether-linked cationic lipids for gene delivery.
作者信息
Ren T, Liu D
机构信息
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA.
出版信息
Bioorg Med Chem Lett. 1999 May 3;9(9):1247-50. doi: 10.1016/s0960-894x(99)00187-0.
Abstract
Quaternary ammonium lipids 1b-d, with diether linkages between hydrocarbon chains and butane or hexane backbone, were synthesized for cationic liposome-mediated gene delivery. The synthetic strategy of using C-4 or C-6 synthon permits the achievement of the variation of the hydrophobic domain as well as changes of space between the quaternary ammonium head and the hydrophobic domain in the diether-linked cationic lipids.
摘要
合成了具有烃链与丁烷或己烷主链之间二醚键的季铵脂质1b - d，用于阳离子脂质体介导的基因递送。使用C - 4或C - 6合成子的合成策略能够实现疏水结构域的变化以及二醚连接的阳离子脂质中季铵头基与疏水结构域之间空间的改变。
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