Liu Dongliang, Hu Jianjun, Qiao Weihong, Li Zongshi, Zhan Shubiao, Cheng Lvbo
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China.
Lipids. 2005 Aug;40(8):839-48. doi: 10.1007/s11745-005-1446-5.
A series of pH-sensitive lipids, la-h [(2,3-bis-alkylcarbamoyloxy-propyl)-trialkylammonium halide] and 2a-d (1-di-methylamino-2,3-bis-alkylcarbamoyloxy-propane), with carbamate linkages between the hydrocarbon chains and an ammonium or tertiary amine head, were synthesized for liposome-mediated gene delivery. The variable length of the carbon chains and the quaternary ammonium or neutral tertiary amine heads allowed us to identify the structure-function relationship showing how these factors would affect cationic lipids in gene delivery performance.
合成了一系列对pH敏感的脂质，即la-h [（2,3-双烷基氨基甲酰氧基丙基）-三烷基卤化铵]和2a-d（1-二甲基氨基-2,3-双烷基氨基甲酰氧基丙烷），它们在烃链与铵或叔胺头部之间具有氨基甲酸酯键，用于脂质体介导的基因递送。碳链长度的变化以及季铵或中性叔胺头部使我们能够确定结构-功能关系，以显示这些因素如何影响阳离子脂质的基因递送性能。
