de Pablo M A, Gaforio J J, Gallego A M, Ortega E, Gálvez A M, Alvarez de Cienfuegos López G
University of Jaén, Department of Health Sciences, Spain.
FEMS Immunol Med Microbiol. 1999 May;24(1):35-42. doi: 10.1111/j.1574-695X.1999.tb01262.x.
The effect of nisin on the immune response of mice was studied. Nisin (in the form of the commercial preparation Nisaplin) was incorporated in the diet of experimental mice which were fed for 30, 75 or 100 days. Short-term administration of diets containing Nisaplin induced an increase of both CD4 and CD8 T-lymphocyte cell counts and also a decrease of B-lymphocyte counts. After prolonged diet administration, T-cell counts returned to control levels. Normal levels of B-lymphocytes were also reached after prolonged administration of the lower (but not the higher) Nisaplin concentration. The macrophage/monocyte fraction isolated from peripheral blood became significantly increased after long-term administration (100 days) of Nisaplin-containing diets in a concentration-dependent way. Although the number of peritoneal cells was not affected by the diets, the phagocytic activity of peritoneal cells decreased after prolonged administration of low (but not high) Nisaplin doses.
研究了乳酸链球菌素对小鼠免疫反应的影响。将乳酸链球菌素（以商业制剂Nisaplin的形式）添加到实验小鼠的饮食中，喂养30、75或100天。短期给予含Nisaplin的饮食会导致CD4和CD8 T淋巴细胞计数增加，同时B淋巴细胞计数减少。长期给予饮食后，T细胞计数恢复到对照水平。长期给予较低（而非较高）浓度的Nisaplin后，B淋巴细胞也达到正常水平。长期（100天）给予含Nisaplin的饮食后，从外周血分离出的巨噬细胞/单核细胞比例以浓度依赖的方式显著增加。尽管饮食对腹腔细胞数量没有影响，但长期给予低剂量（而非高剂量）的Nisaplin后，腹腔细胞的吞噬活性降低。
