Weinstein B M
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
Dev Dyn. 1999 May;215(1):2-11. doi: 10.1002/(SICI)1097-0177(199905)215:1<2::AID-DVDY2>3.0.CO;2-U.
Survival of vertebrate embryos depends on their ability to assemble a correctly patterned, integrated network of blood vessels to supply oxygen and nutrients to developing tissues. The arrangement of larger caliber intraembryonic vessels, specification of arterial-venous identity, and proper placement of major branch points and arterial-venous connections are all precisely determined. A number of recent studies in both mammalian and nonmammalian vertebrate species, reviewed here, have now begun to reveal the major role played by genetically predetermined extrinsic cues in guiding the formation of early embryonic blood vessels and determining the global pattern of the vasculature.
脊椎动物胚胎的存活取决于它们构建一个模式正确、完整的血管网络的能力，该网络可为发育中的组织提供氧气和营养物质。较大口径的胚胎内血管的排列、动静脉身份的确定以及主要分支点和动静脉连接的正确定位都是精确决定的。本文综述的最近一些关于哺乳动物和非哺乳动物脊椎动物物种的研究，现已开始揭示基因预先决定的外在线索在引导早期胚胎血管形成和确定脉管系统整体模式中所起的主要作用。
