Joko S, Numaga J, Maeda H
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Jpn J Ophthalmol. 1999 Mar-Apr;43(2):97-102. doi: 10.1016/s0021-5155(98)00068-9.
To identify any possible determinants in the development of uveitis in leprosy patients.
Human leukocyte antigen (HLA) class I and II antigen, and HLA class II genotypings were analyzed among Japanese leprosy patients. Ninety-three unrelated Japanese leprosy patients (46 patients with a history of uveitis and 47 patients without uveitis) and 114 healthy control subjects were investigated.
The occurrence of HLA-DR2 was significantly higher in patients with uveitis (78.3%) than in those without uveitis (57.4%; odds ratio = 2.7, P<.05) and in the controls (33.3%; odds ratio = 7.2, P<.0000005, Pc<.00005). The occurrence of HLA-DR4 was significantly lower in patients with uveitis (15.2%) than in those without it (38.3%; odds ratio = 0.29, P<.05) and in the controls (46.5%; odds ratio = 0.21, P<.0005, Pc<.05). Furthermore, the frequencies of DR2-positive and DR4-negative genotypes were significantly higher in patients with uveitis (69.6%) than in those without it (38.3%; odds ratio = 3.7, P<.005) and in the controls (21.9%; odds ratio = 8.1, P<.00000005). At the genomic level, the occurrence of HLA-DQB10302 was significantly lower in the patients with uveitis (8.7%) than in those without it (25.5%; odds ratio = 0.28, P<.05). The distribution of HLA-DRB1 and DQA1 alleles was not significantly different between the patients with and those without uveitis. However, the frequencies of DRB11501-positive, as well as DRB10405- and DQB10302-negative genotypes were significantly higher in the patients with uveitis (47.8%) than in those without it (25.5%; odds ratio = 2.7, P<.05) and in the controls (8.8%; odds ratio = 9.5, P<.00000005).
Our results suggest that HLA Class II genes confer susceptibility to or protection from leprous uveitis.
确定麻风患者葡萄膜炎发生过程中可能的决定因素。
对日本麻风患者进行人类白细胞抗原（HLA）Ⅰ类和Ⅱ类抗原及HLAⅡ类基因分型分析。调查了93名无亲缘关系的日本麻风患者（46例有葡萄膜炎病史患者和47例无葡萄膜炎患者）以及114名健康对照者。
葡萄膜炎患者中HLA - DR2的出现率（78.3%）显著高于无葡萄膜炎患者（57.4%；优势比 = 2.7，P <.05）和对照组（33.3%；优势比 = 7.2，P <.0000005，Pc <.00005）。葡萄膜炎患者中HLA - DR4的出现率（15.2%）显著低于无葡萄膜炎患者（38.3%；优势比 = 0.29，P <.05）和对照组（46.5%；优势比 = 0.21，P <.0005，Pc <.05）。此外，葡萄膜炎患者中DR2阳性和DR4阴性基因型的频率（69.6%）显著高于无葡萄膜炎患者（38.3%；优势比 = 3.7，P <.005）和对照组（21.9%；优势比 = 8.1，P <.00000005）。在基因水平上，葡萄膜炎患者中HLA - DQB10302的出现率（8.7%）显著低于无葡萄膜炎患者（25.5%；优势比 = 0.28，P <.05）。有葡萄膜炎患者和无葡萄膜炎患者之间HLA - DRB1和DQA1等位基因的分布无显著差异。然而，葡萄膜炎患者中DRB11501阳性以及DRB10405和DQB10302阴性基因型的频率（47.8%）显著高于无葡萄膜炎患者（25.5%；优势比 = 2.7，P <.05）和对照组（8.8%；优势比 = 9.5，P <.00000005）。
我们的结果表明，HLAⅡ类基因赋予对麻风性葡萄膜炎的易感性或保护性。
