正常月经周期中的血清血管内皮生长因子（VEGF）：与卵巢和子宫多普勒血流变化的关联

Serum vascular endothelial growth factor (VEGF) in the normal menstrual cycle: association with changes in ovarian and uterine Doppler blood flow.

作者信息

Agrawal R, Conway G S, Sladkevicius P, Payne N N, Bekir J, Campbell S, Tan S L, Jacobs H S

机构信息

University College London Medical School, The Middlesex Hospital.

出版信息

Clin Endocrinol (Oxf). 1999 Jan;50(1):101-6. doi: 10.1046/j.1365-2265.1999.00618.x.

DOI:10.1046/j.1365-2265.1999.00618.x

PMID:10341862

Abstract

OBJECTIVE

To investigate whether changes in circulating serum vascular endothelial growth factor (VEGF) concentrations during the menstrual cycle are associated with changes in blood flow within the ovaries and uterus.

PATIENTS AND MEASUREMENTS

Serum VEGF concentrations were measured and pulsed and colour Doppler blood flow waveforms recorded within the ovarian stroma and uterine arteries during the early follicular, the immediate preovulatory and the mid-luteal phases of the menstrual cycle of 14 healthy women.

RESULTS

Mean (+/- SD) serum VEGF concentrations rose from 2.44 +/- 0.1 ng/ml in the early follicular phase to 3 +/- 0.8 ng/ml in the pre-ovulatory phase and to 4.4 +/- 0.9 ng/ml in the mid-luteal phase (P < 0.0001) of the menstrual cycle. Mean peak systolic blood flow velocity (PSV) and time-averaged maximum flow velocity (TAMXV) were higher within the ovarian stroma of the ovary bearing the dominant follicle and the uterine arteries in the pre-ovulatory and mid-luteal phase than in the same sites during the early follicular phase of the menstrual cycle. PSV rose significantly from the early follicular phase (11 +/- 6 cm/s) to 14 +/- 4 cm/s in the pre-ovulatory phase and further in the mid-luteal phase (26 +/- 7 cm/s, P = 0.0001). Within the uterine arteries, mean PSV rose significantly from 28 +/- 9 cm/s in the early follicular phase to 31 +/- 8 cm/s in the pre-ovulatory phase and further in the mid-luteal phase (44 +/- 11 cm/s, P < 0.005). Serum VEGF correlated with serum progesterone concentrations in the luteal phase (r = 0.85, P < 0.001), with serum oestradiol concentrations in the early follicular (r = 0.67, P = 0.009), pre-ovulatory (r = 0.57, P = 0.03) and luteal phases (r = 0.68, P < 0.005) and with serum testosterone in the early follicular phase (r = 0.63, P = 0.01).

CONCLUSIONS

Cyclical changes in serum vascular endothelial growth factor concentrations are associated with coincident changes in ovarian and uterine blood flow.

摘要

目的

研究月经周期中循环血清血管内皮生长因子（VEGF）浓度的变化是否与卵巢和子宫内血流变化相关。

患者与测量

对14名健康女性月经周期的卵泡早期、排卵前期和黄体中期，测量血清VEGF浓度，并记录卵巢基质和子宫动脉内的脉冲及彩色多普勒血流波形。

结果

月经周期中，血清VEGF平均（±标准差）浓度从卵泡早期的2.44±0.1 ng/ml升至排卵前期的3±0.8 ng/ml，再升至黄体中期的4.4±0.9 ng/ml（P<0.0001）。在排卵前期和黄体中期，优势卵泡所在卵巢的卵巢基质及子宫动脉内的平均收缩期峰值血流速度（PSV）和时间平均最大血流速度（TAMXV）高于月经周期卵泡早期的相同部位。PSV从卵泡早期的11±6 cm/s显著升至排卵前期的14±4 cm/s，并在黄体中期进一步升高至26±7 cm/s（P = 0.0001）。在子宫动脉内，平均PSV从卵泡早期的28±9 cm/s显著升至排卵前期的31±8 cm/s，并在黄体中期进一步升高至44±11 cm/s（P<0.005）。血清VEGF在黄体期与血清孕酮浓度相关（r = 0.85，P<0.001），在卵泡早期（r = 0.67，P = 0.009）、排卵前期（r = 0.57，P = 0.03）和黄体期（r = 0.68，P<0.005）与血清雌二醇浓度相关，在卵泡早期与血清睾酮相关（r = 0.63，P = 0.01）。