Rasmussen L S, Christiansen M, Hansen P B, Moller J T
Department of Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Denmark.
Acta Anaesthesiol Scand. 1999 May;43(5):495-500. doi: 10.1034/j.1399-6576.1999.430502.x.
Neuron-specific enolase (NSE) and S-100 protein have been used as markers for major brain damage. Cognitive dysfunction after cardiac surgery represents subtle brain damage that is detected by neuropsychological testing. We hypothesised that blood levels of NSE and S-100 protein would increase after coronary artery bypass surgery and that the change in blood level would correlate with the change in cognitive function.
We included 35 elderly patients undergoing coronary artery bypass surgery. Neuropsychological testing was performed before surgery and postoperatively at discharge from hospital and after 3 months using a neuropsychological test battery. Serum levels of NSE and S-100 protein were measured before surgery and postoperatively after 24 h and 48 h.
Serum level of both NSE and S-100 protein increased significantly 24 and 48 h after coronary artery bypass. Only the increase in NSE after 24 h was found to correlate with the degree of cognitive dysfunction at discharge from hospital. The increase in S-100 protein after 24 h correlated significantly with the duration of cardiopulmonary bypass.
NSE seems to be a useful blood marker for early cognitive dysfunction after coronary artery bypass surgery.
神经元特异性烯醇化酶（NSE）和S-100蛋白已被用作严重脑损伤的标志物。心脏手术后的认知功能障碍代表了通过神经心理学测试检测到的轻微脑损伤。我们假设冠状动脉搭桥手术后NSE和S-100蛋白的血液水平会升高，并且血液水平的变化与认知功能的变化相关。
我们纳入了35例接受冠状动脉搭桥手术的老年患者。术前、出院时术后以及术后3个月使用一套神经心理学测试进行神经心理学测试。术前以及术后24小时和48小时测量NSE和S-100蛋白的血清水平。
冠状动脉搭桥术后24小时和48小时，NSE和S-100蛋白的血清水平均显著升高。仅发现术后24小时NSE的升高与出院时认知功能障碍的程度相关。术后24小时S-100蛋白的升高与体外循环时间显著相关。
NSE似乎是冠状动脉搭桥手术后早期认知功能障碍的一种有用的血液标志物。
