Veikkola T, Alitalo K
Molecular/Cancer Biology Laboratory, Haartman Institute (Haatmaninkatu 3), 00014 University of Helsinki, Finland.
Semin Cancer Biol. 1999 Jun;9(3):211-20. doi: 10.1006/scbi.1998.0091.
Angiogenesis, the formation of new blood vessels from pre--existing ones, is central for both normal development and homeostasis as well as in certain pathological conditions. The vascular endothelial growth factors (VEGFs) and their receptors are prime regulators of both physiological and pathological angiogenesis. The different VEGFs have overlapping but specific roles in controlling the growth of new blood vessels. The VEGF receptors transduce signals mediating endothelial cell proliferation, migration, organization into functional vessels and remodeling of the vessel network. In recent years, rapid progress has been made in understanding the receptor-ligand interactions that orchestrate the neovascularization process.
血管生成，即从已有的血管形成新的血管，对于正常发育和体内平衡以及某些病理状况而言都至关重要。血管内皮生长因子（VEGF）及其受体是生理性和病理性血管生成的主要调节因子。不同的VEGF在控制新血管生长方面具有重叠但特定的作用。VEGF受体转导介导内皮细胞增殖、迁移、组织形成功能性血管以及血管网络重塑的信号。近年来，在理解协调新血管形成过程的受体-配体相互作用方面取得了快速进展。
