Shibuya M
Department of Genetics, University of Tokyo, Japan.
Hum Cell. 1999 Mar;12(1):17-24.
Angiogenesis is a crucial biological process not only in the formation of cardiovascular system and organization of tissues in embryo but also in a variety of diseases including solid tumor growth and diabetic retinopathy. Several protein factors crucial for regulation of angiogenesis have recently been identified. Among these factors, VEGF is considered to be the most important regulator for vascular endothelial cell growth and differentiation both in physiological and pathological conditions. Relationship between VEGF and other regulatory factors such as Angiopoietins should be elucidated to further understand the dynamic process of angiogenesis.
血管生成是一个关键的生物学过程，不仅在胚胎期心血管系统的形成和组织构建中发挥作用，而且在包括实体瘤生长和糖尿病视网膜病变在内的多种疾病中也具有重要意义。最近已鉴定出几种对血管生成调节至关重要的蛋白质因子。在这些因子中，血管内皮生长因子（VEGF）被认为是生理和病理条件下血管内皮细胞生长和分化的最重要调节因子。为了进一步了解血管生成的动态过程，需要阐明VEGF与其他调节因子（如血管生成素）之间的关系。
