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血管内皮生长因子、血管抑素和内皮抑素在鼻息肉发生发展中的作用

The Roles of Vascular Endothelial Growth Factor, Angiostatin, and Endostatin in Nasal Polyp Development.

作者信息

Hong Tae Ui, Park Seong Kook

机构信息

Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Inje University, Busan, Republic of Korea.

出版信息

J Rhinol. 2022 Jul;29(2):82-87. doi: 10.18787/jr.2021.00400. Epub 2022 Jul 27.

DOI:10.18787/jr.2021.00400
PMID:39665059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11540239/
Abstract

BACKGROUND AND OBJECTIVES

Microvascular remodeling and angiogenesis are elements of tissue remodeling characteristic of chronic inflammatory diseases, including nasal polyps (NPs). Angiogenesis reflects the balance between the actions of pro- and anti-angiogenic factors. Many pro-angiogenic factors are known, including vascular endothelial growth factor (VEGF). A number of anti-angiogenic factors (e.g., angiostatin and endostatin) also has been identified. Our objective was to assess the roles of VEGF, angiostatin, and endostatin in NP development.

METHODS

The expression levels of VEGF, angiostatin, and endostatin were measured in NPs harvested during endoscopic endonasal surgery and compared with those in inferior turbinate mucosa (control) samples acquired from patients with hypertrophic rhinitis without allergy. Western blotting and immunohistochemical staining were used to analyze all samples.

RESULTS

The levels of VEGF and angiostatin were significantly higher in the NP subjects than in the controls. Neither the VEGF/angiostatin ratio nor the endostatin level differed significantly between the two groups. However, the VEGF/endostatin ratio was significantly higher in the NP than in the control group. Both the NP and control tissues were diffusely immunoreactive for VEGF, angiostatin, and endostatin.

CONCLUSION

NP-associated hypoxia can elevate angiostatin level; moreover, an imbalance in the VEGF/endostatin ratio can contribute to NP formation.

摘要

背景与目的

微血管重塑和血管生成是慢性炎症性疾病（包括鼻息肉（NP））组织重塑的特征性要素。血管生成反映了促血管生成因子和抗血管生成因子作用之间的平衡。已知许多促血管生成因子，包括血管内皮生长因子（VEGF）。也已鉴定出一些抗血管生成因子（如血管抑素和内皮抑素）。我们的目的是评估VEGF、血管抑素和内皮抑素在NP发生发展中的作用。

方法

在内镜下鼻内手术中采集NP样本，测量其中VEGF、血管抑素和内皮抑素的表达水平，并与从无过敏的肥厚性鼻炎患者获取的下鼻甲黏膜（对照）样本中的表达水平进行比较。采用蛋白质印迹法和免疫组织化学染色法分析所有样本。

结果

NP组受试者的VEGF和血管抑素水平显著高于对照组。两组之间VEGF/血管抑素比值和内皮抑素水平均无显著差异。然而，NP组的VEGF/内皮抑素比值显著高于对照组。NP组织和对照组织对VEGF、血管抑素和内皮抑素均呈弥漫性免疫反应。

结论

NP相关的缺氧可提高血管抑素水平；此外，VEGF/内皮抑素比值失衡可能促成NP的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/5c61b2b4a97d/jr-2021-00400f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/7113cf3a20c2/jr-2021-00400f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/33ff3776fa22/jr-2021-00400f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/250ed6a0e4d5/jr-2021-00400f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/5c61b2b4a97d/jr-2021-00400f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/7113cf3a20c2/jr-2021-00400f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/33ff3776fa22/jr-2021-00400f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/250ed6a0e4d5/jr-2021-00400f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0137/11540239/5c61b2b4a97d/jr-2021-00400f4.jpg

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