Saito M, Nakayama K, Nakagawa M
Jikken Dobutsu. 1976 Oct;25(4):265-72.
Localization of Mycoplasma pulmonis was examined in mice infected by direct contact with previously infected mice. After contact with infected animals, the organisms were shown to become detectable first in the nasal and oral cavities and trachea on the next day, and then they were recovered from the middle ear and brain after 3 and 4 days, respectively. After 7 days of contact, isolation rates retained to be 100% in the nasal, oral and tracheal cavities, while 95% in the middle ear and brain, 25% in the lung and 20% in the vagina and uterus. The number of colonies was the most numerous from the nasal, uterine and vaginal cavities, followed by the trachea, middle ear, oral cavity, brain and lung in this order, except for a few mice having pneumonic lesions giving a large number of the organisms. The isolation rates with these organs were not changed even after 6 weeks of contact and organisms were never detected from the liver, spleen, kidney and heart. Mice from a naturally infected breeding colony showed similar finding to those sacrificed after 6 weeks of experimental contact.
通过与先前感染的小鼠直接接触感染小鼠，研究了肺支原体的定位情况。与感染动物接触后，结果显示这些微生物在次日首先可在鼻腔、口腔和气管中被检测到，然后分别在3天和4天后从中耳和大脑中分离出来。接触7天后，鼻腔、口腔和气管中的分离率保持在100%，而中耳和大脑中的分离率为95%，肺中的分离率为25%，阴道和子宫中的分离率为20%。除了少数患有肺部病变且含有大量该微生物的小鼠外，菌落数量从鼻腔、子宫和阴道中最多，其次依次为气管、中耳、口腔、大脑和肺。即使接触6周后，这些器官的分离率也没有变化，并且从未在肝脏、脾脏、肾脏和心脏中检测到微生物。来自自然感染繁殖群体的小鼠显示出与实验接触6周后处死的小鼠相似的结果。
