Yanaura S, Ishikawa S
Nihon Yakurigaku Zasshi. 1976 Sep;72(6):689-700.
Effects of some bile acids on the biliary flow, BSP output and composition (phospholipid, cholesterol, bilirubin and bile acids) were studied in dogs. Ursodeoxycholic acid (UD), chenodeoxycholic acid (CD) and dehydrocholic acid (DC) caused a dramatic increase in biliary flow and BSP output. Relative potencies of these effects were DC greater than CD greater than or equal to UD. UD increased the phospholipid, bile acids and cholesterol concentration but had little effect on bilirubin concentration. Furthermore, UD greatly increased the output of four bile components. CD slightly decreased the phospholipid, cholesterol and bilirubin concentration without the bile acids, while CD increased the output of bile components. After UD or CD administration, the bile acid of each appeared markedly in the bile, dose dependently. On the other hand, DC caused a dramatic decrease of phospholipid, cholesterol and bilirubin concentration but had little effect on bile acids concentration. Output of bile components was increased by DC the first 1 hr but decreased at 2 hr. After DC administration, 3alpha, 7alpha-dihydroxy-12keto-5beta-cholanic acid appeared in the bile while DC did not. Therefore, it is concluded that UD and CD are cholanereticas and DC is a hydrocholeretica.
研究了某些胆汁酸对犬胆汁流量、BSP排出量及胆汁成分（磷脂、胆固醇、胆红素和胆汁酸）的影响。熊去氧胆酸（UD）、鹅去氧胆酸（CD）和去氢胆酸（DC）可使胆汁流量和BSP排出量显著增加。这些作用的相对强度为DC大于CD大于或等于UD。UD可增加磷脂、胆汁酸和胆固醇浓度，但对胆红素浓度影响不大。此外，UD可大幅增加四种胆汁成分的排出量。CD可使不含胆汁酸时的磷脂、胆固醇和胆红素浓度略有降低，而CD可增加胆汁成分的排出量。给予UD或CD后，各自的胆汁酸均显著出现在胆汁中，呈剂量依赖性。另一方面，DC可使磷脂、胆固醇和胆红素浓度显著降低，但对胆汁酸浓度影响不大。胆汁成分的排出量在给予DC后的第1小时增加，但在第2小时减少。给予DC后，3α，7α-二羟基-12酮-5β-胆烷酸出现在胆汁中，而DC本身未出现。因此，得出结论：UD和CD是利胆剂，而DC是促胆汁分泌剂。
