Yoshida K, Nakamura H
Hokkaido Igaku Zasshi. 1976 Sep;51(5):371-5.
The comparative radioisotopic studies in cholesterol metabolism between salivary glands and livers were done. 1. In the salivary glands, the cholesterol biosynthesis from acetate-1-14C or mevalonic acid-2-14C in vitro and in vivo, the elimination rate of cholesterol-4-14C and the uptake of cholesterol-4-14C following a single subcutaneous injection, were lowered compared with liver. 2. The rate of cholesterol catabolism in the salivary gland, determined by cholesterol-4-14C injection, were very less than in liver. 3. When the animals were consuming a diet labeled with cholesterol-3H of constant specific activity using cholesterol balance techniques, the isotopic steady state in both salivary gland and liver was within about 20 days and remained essentially constant thereafter, while specific activity of the salivary glands were remarkably lower than that of livers.
开展了唾液腺与肝脏胆固醇代谢的放射性同位素对比研究。1. 在唾液腺中，与肝脏相比，体外和体内由乙酸-1-¹⁴C或甲羟戊酸-2-¹⁴C合成胆固醇的过程、胆固醇-4-¹⁴C的消除率以及单次皮下注射后胆固醇-4-¹⁴C的摄取量均降低。2. 通过注射胆固醇-4-¹⁴C测定，唾液腺中胆固醇的分解代谢速率远低于肝脏。3. 当动物采用胆固醇平衡技术食用具有恒定比活度的³H标记胆固醇的饮食时，唾液腺和肝脏中的同位素稳态在约20天内达到，此后基本保持恒定，而唾液腺的比活度明显低于肝脏。
