Henderson K M
J Endocrinol. 1976 Nov;71(2):259-63. doi: 10.1677/joe.0.0710259.
16-Aryloxy analogues of prostaglandin F2alpha (PGF2alpha) are potent luteolysins in laboratory and farm animals. When their effect on progesterone production by luteinized human granulosa cells in tissue culture was investigated inhibition of both basal gonadotrophin-stimulated progesterone production was observed, so revealing characteristics expected of potential human luteolysins. The analogues were, however, unable to inhibit progesterone production stimulated by PGE2, suggesting that like PGF2alpha these compounds may act by specifically blocking LH-activated adenylate cyclase. The 16-aryloxyprostaglandins similarly inhibited progesterone production by porcine granulosa cells, so that the effects observed with the 16-aryloxyprostaglandins in vitro may be indicative of their potential in vivo.
前列腺素F2α（PGF2α）的16 - 芳氧基类似物在实验动物和家畜中是强效黄体溶解素。在研究它们对组织培养中黄体化人颗粒细胞产生孕酮的影响时，观察到对基础促性腺激素刺激的孕酮产生均有抑制作用，从而揭示了潜在人类黄体溶解素应有的特征。然而，这些类似物无法抑制PGE2刺激的孕酮产生，这表明与PGF2α一样，这些化合物可能通过特异性阻断LH激活的腺苷酸环化酶发挥作用。16 - 芳氧基前列腺素同样抑制猪颗粒细胞产生孕酮，因此在体外观察到的16 - 芳氧基前列腺素的作用可能表明它们在体内的潜力。
