聚合钆螯合物磁共振成像造影剂：设计、合成与性质

Polymeric gadolinium chelate magnetic resonance imaging contrast agents: design, synthesis, and properties.

作者信息

Ladd D L, Hollister R, Peng X, Wei D, Wu G, Delecki D, Snow R A, Toner J L, Kellar K, Eck J, Desai V C, Raymond G, Kinter L B, Desser T S, Rubin D L

机构信息

Torsten Almén Research Center, Nycomed Amersham Imaging, 466 Devon Park Drive, Wayne, Pennsylvania 19087, USA.

出版信息

Bioconjug Chem. 1999 May-Jun;10(3):361-70. doi: 10.1021/bc980086+.

DOI:10.1021/bc980086+

PMID:10346865

Abstract

We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physical properties including molecular weight, relaxivity, metal content, viscosity, and chelate stability could be varied. We have shown that, by selecting polymers of the appropriate MW, extended blood pool retention can be achieved. In addition, relaxivity can be manipulated by changing the polymer rigidity, metal content affected by monomer selection, viscosity by polymer shape, and chelate stability by chelator selection.

摘要

我们合成并评估了五个系列的聚合钆螯合物，它们作为潜在的磁共振成像血池造影剂具有研究价值。这些聚合物的设计使得包括分子量、弛豫率、金属含量、粘度和螯合物稳定性在内的重要物理性质可以改变。我们已经表明，通过选择合适分子量的聚合物，可以实现延长的血池保留时间。此外，弛豫率可以通过改变聚合物刚性来控制，金属含量受单体选择影响，粘度受聚合物形状影响，螯合物稳定性受螯合剂选择影响。