Puerta David T, Botta Mauro, Jocher Christoph J, Werner Eric J, Avedano Stefano, Raymond Kenneth N, Cohen Seth M
Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA 92093, USA.
J Am Chem Soc. 2006 Feb 22;128(7):2222-3. doi: 10.1021/ja057954f.
Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.
已制备出两种基于三脚架型六齿吡喃的螯合剂。这些配体与钆（III）形成稳定、可溶的配合物。在pH 7.4时，这些配合物在水溶液中的稳定性与[Gd（DTPA）]2-相当。弛豫测量评估表明，这些配合物有两个内球水分子且水交换速率非常快。这些配合物的溶液行为表明，作为高弛豫率的下一代磁共振成像造影剂，它们可能具有吸引力。
