Mompeõ B, Ortega F, Sarmiento L, Castaño I
Centro de Ciencias de la Salud, University of Las Palmas de Gran Canaria, Spain.
Ann Vasc Surg. 1999 May;13(3):294-301. doi: 10.1007/s100169900260.
The aim of this study was to document similarities and differences between veins from human diabetic patients and an experimentally induced diabetic animal model. The saphenous vein and posterior tibial vein from diabetic patients and the femoral vein from rats were studied. An increase in the extracellular matrix with migration of smooth muscle cells and endothelial alterations were observed in the intima of all specimens. These findings demonstrate that there is a high degree of similarity between the pathological changes in the venous wall during human diabetes mellitus and streptozotocin (STZ) induced-diabetes. This finding validates STZ induced-diabetes in rats as a model for further experimental study to clarify the fate of the diabetic venous wall when used as a graft.
本研究的目的是记录人类糖尿病患者的静脉与实验性诱导糖尿病动物模型的静脉之间的异同。研究了糖尿病患者的大隐静脉和胫后静脉以及大鼠的股静脉。在所有标本的内膜中均观察到细胞外基质增加、平滑肌细胞迁移和内皮改变。这些发现表明，人类糖尿病和链脲佐菌素（STZ）诱导的糖尿病期间静脉壁的病理变化之间存在高度相似性。这一发现验证了大鼠STZ诱导的糖尿病作为进一步实验研究的模型，以阐明糖尿病静脉壁用作移植物时的转归。
