Tesseromatis C, Kotsiou A, Parara H, Vairaktaris E, Tsamouri M
Department of Pharmacology, Medical School, University of Athens, Mikras Assias 75, 11527 Goudi, Greece.
Int J Dent. 2009;2009:725628. doi: 10.1155/2009/725628. Epub 2009 Jan 27.
Gingivitis and periodontitis are chronic bacterial diseases of the underlying and surrounding tooth tissues. Diabetes mellitus is responsible for tooth deprivation both by decay and periodontal disease. The streptozotocin-induced diabetes results in a diabetic status in experimental animals similar to that observed in diabetes patients. The aim of the study was to investigate the relationship between the gingival lesions and the microangiopathy changes in streptozotocin-induced diabetes mellitus. Forty male Wistar rats were divided into two groups (control and experimental). Diabetes mellitus was induced by 45 mg/kg IV streptozotocin. The histological investigation of the marginal gingival and the relevant gingival papilla showed inflammation of the lamina propria and the squamous epithelium as well as marked thickness of the arteriole in the diabetic group, but no changes were observed in the control group. The results suggested a probable application of a routine gingival histological investigation in diabetic patients in order to control the progress of disease complications. It may be concluded that histological gingival investigation can be used as a routine assay for the control of the diabetic disease and prevention of its complications.
牙龈炎和牙周炎是牙齿深层及周围组织的慢性细菌性疾病。糖尿病会因龋齿和牙周疾病导致牙齿缺失。链脲佐菌素诱导的糖尿病会使实验动物出现与糖尿病患者相似的糖尿病状态。本研究的目的是调查链脲佐菌素诱导的糖尿病中牙龈病变与微血管病变变化之间的关系。40只雄性Wistar大鼠被分为两组（对照组和实验组）。通过静脉注射45mg/kg链脲佐菌素诱导糖尿病。对边缘龈及相关牙龈乳头的组织学研究显示，糖尿病组固有层和鳞状上皮有炎症，小动脉明显增厚，而对照组未观察到变化。结果表明，对糖尿病患者进行常规牙龈组织学检查可能有助于控制疾病并发症的进展。可以得出结论，牙龈组织学检查可作为控制糖尿病及其并发症的常规检测方法。
