Ahrns K S, Harkins D R
University of Michigan Trauma Burn Center, Saline 48176, USA.
AACN Clin Issues. 1999 Feb;10(1):46-60.
Thermal injury disrupts normal hemostasis and sets off a cascade of events: cellular alterations and release of inflammatory mediators cause hypovolemic and cellular shock. Fluid resuscitation in burn injuries has been in use for more than a century, and much research has been devoted to development of resuscitation formulas and appropriate choice of fluid. Parameters for adequate monitoring of resuscitation are greatly debated. Current research efforts focus on minimizing burn edema through mediator modulation and on development of definitive endpoints of resuscitation monitoring.
热损伤会破坏正常的止血功能，并引发一系列事件：细胞改变和炎症介质释放会导致低血容量性休克和细胞性休克。烧伤后的液体复苏已经使用了一个多世纪，并且有大量研究致力于复苏公式的开发和液体的合理选择。关于复苏充分监测的参数存在很大争议。当前的研究工作集中在通过介质调节来尽量减少烧伤水肿以及确定复苏监测的明确终点。
