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[小儿胃食管反流的食管腹段超声检查:内镜与组织病理学数据的相关性]

[Esophageal intra-abdominal ultrasonographic in children with gastroesophageal reflux: correlation between endoscopic and histopathologic data].

作者信息

Antunes M M, Yamada R M, Trevisan M, Cardoso S R, Servidoni M de F, Hessel G

机构信息

Departamento de Pediatria, Faculdade de Ciências Médicas da Universidade Estadual de Campinas, FCM/UNICAMP, SP.

出版信息

Arq Gastroenterol. 1998 Oct-Dec;35(4):292-9.

Abstract

Gastroesophageal reflux disease has been very often in children and one of its most critical complications is the peptic esophagitis disease. The diagnosis of peptic esophagitis is obtained based on the endoscopic changes and the histologic features. The pressure reduction of the lower esophageal sphincter is one of the elements of the esophagitis pathogenesis. The pressure is related with the length of the esophageal abdominal segment, which can be measured by ultrasonography. The research presented in this paper aims to relate ultrasonographic measurements of esophageal abdominal segment length with endoscopic changes and with esophageal biopsy obtained from children with gastroesophagel reflux disease. We submitted 16 children with gastroesophagel reflux disease, between 10 and 156 months old (median 63.5 months old), to endoscopy and to esophageal biopsy. We verified the following results from endoscopy and biopsy: six of the 16 patients had endoscopic peptic esophagitis and, in five of these (six patients), the same diagnosis was confirmed by biopsy. Ten of the 16 patients had normal endoscopy, but the biopsy of four of these 10 patients showed histologic changes compatible with esophagitis. We observed no relationship between endoscopy and biopsy, when all degrees of histologic change were used to diagnose esophagitis. However, we found high relationship when the mild histologic changes were considered as only a consequence of the reflux. We verified the following results from ultrasonography: five of the six patients with endoscopic peptic esophagitis and all patients with esophagitis determined by biopsy (excluding those with mild histologic changes) had reduced esophageal abdominal segment length. In conclusion, we have found relationship between endoscopic changes and histologic features in the diagnosis of esophagitis and correlation between the reduced esophageal abdominal segment length and the presence of esophagitis.

摘要

胃食管反流病在儿童中非常常见,其最严重的并发症之一是消化性食管炎。消化性食管炎的诊断基于内镜检查结果和组织学特征。食管下括约肌压力降低是食管炎发病机制的因素之一。该压力与食管腹段长度有关,食管腹段长度可通过超声测量。本文提出的研究旨在将食管腹段长度的超声测量结果与内镜检查结果以及从胃食管反流病患儿获取的食管活检结果相关联。我们对16名年龄在10至156个月(中位数为63.5个月)的胃食管反流病患儿进行了内镜检查和食管活检。我们从内镜检查和活检中得到了以下结果:16名患者中有6名患有内镜下消化性食管炎,其中5名(6名患者中的)经活检确诊为同一诊断。16名患者中有10名内镜检查正常,但这10名患者中的4名活检显示有与食管炎相符的组织学改变。当使用所有程度的组织学改变来诊断食管炎时,我们观察到内镜检查和活检之间没有相关性。然而,当仅将轻度组织学改变视为反流的结果时,我们发现两者有高度相关性。我们从超声检查中得到了以下结果:6名内镜下患有消化性食管炎的患者中有5名以及所有经活检确诊为食管炎的患者(不包括那些有轻度组织学改变的患者)食管腹段长度缩短。总之,我们发现在食管炎诊断中内镜检查结果与组织学特征之间存在关联,以及食管腹段长度缩短与食管炎的存在之间存在相关性。

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