Niki Y, Watanabe S, Tamada S, Yoshida K, Miyashita N, Nakajima M, Matsushima T, Sekino H, Matsuoka O
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.
Antimicrob Agents Chemother. 1999 Jun;43(6):1494-6. doi: 10.1128/AAC.43.6.1494.
The effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum in healthy male volunteers was investigated. The concentration of theophylline in serum and the urinary excretion rates of theophylline on day 5 of concomitant dosing with HSR-903 tended to increase compared to those on day 4, when theophylline was given alone; however, the urinary excretion rates of 1-methyluric acid and 3-methylxanthine on day 5 of concomitant dosing with HSR-903 tended to decrease in comparison to those on day 4, when theophylline was given alone.
研究了新型氟喹诺酮类药物HSR - 903对健康男性志愿者血清中茶碱浓度的影响。与单独给予茶碱的第4天相比，在与HSR - 903联合给药的第5天，血清中茶碱浓度和茶碱的尿排泄率有升高趋势；然而，与单独给予茶碱的第4天相比，在与HSR - 903联合给药的第5天，1 - 甲基尿酸和3 - 甲基黄嘌呤的尿排泄率有降低趋势。
