Ganea G R, Bogue C W
Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520-8064, USA.
Curr Opin Pediatr. 1999 Jun;11(3):207-12. doi: 10.1097/00008480-199906000-00006.
Over the last 10 years, there has been a fundamental change in physicians' attitudes toward analgesia and sedation in pediatrics. In this time, basic and clinical research have provided a wealth of information. In this paper we review important advances registered in the past year, including new molecular and physiological mechanisms of antinociception and sedation, behavioral and psychoemotional implications of pain, and advances in the clinical practice of pediatric analgesia and sedation. Fortunately, the attitude of physicians toward these matters has changed significantly and much more attention is now paid to the alleviation of pain and provision of adequate sedation. However, there remains, according to most estimates, incongruity between these advances and what is practiced clinically.
在过去十年中，医生对儿科镇痛和镇静的态度发生了根本性变化。在此期间，基础研究和临床研究提供了丰富的信息。在本文中，我们回顾了过去一年取得的重要进展，包括抗伤害感受和镇静的新分子和生理机制、疼痛的行为和心理情绪影响，以及儿科镇痛和镇静临床实践的进展。幸运的是，医生对这些问题的态度已经发生了显著变化，现在更加关注疼痛的缓解和充分镇静的提供。然而，根据大多数估计，这些进展与临床实践之间仍然存在不一致。
