Belitser V A, Varetskaia T V, Tsariuk L A
Ukr Biokhim Zh. 1976;48(6):721-6.
The plasminogen proactivator present in human plasma and retained by purified human fibrinogen preparations is readily accepted and retained by bovine fibrinogen. This "transplantation" makes isolated bovine fibrinogen susceptible to streptokinase. The latter induces degradation of isolated bovine fibrinogen resulting in characteristic fragment formation. Our experimental results, particularly those showing the inability of bovine plasminogen (applied in a great excess) to remove the acquired proactivator from bovine fibrinogen, give indirect evidence that the proactivator function is not a specific property of the human plasminogen but that of some other substance.
人血浆中存在的纤溶酶原激活剂以及纯化的人纤维蛋白原制剂所保留的该激活剂，很容易被牛纤维蛋白原接受并保留。这种“移植”使分离出的牛纤维蛋白原对链激酶敏感。后者会诱导分离出的牛纤维蛋白原发生降解，导致特征性片段形成。我们的实验结果，尤其是那些表明大量应用的牛纤溶酶原无法从牛纤维蛋白原中去除获得性激活剂的结果，间接证明了激活剂功能并非人纤溶酶原的特异性属性，而是其他某种物质的属性。
