Uzunonat G, Emir M, Yamak B, Ulus A T, Ulaş M, Uncu H, Saritaş Z, Katircioğlu S F, Taşdemir O
Cardiovascular Surgery Department of Türkiye Yüksek Ihtisas Hospital of Ankara, Turkey.
J Cardiovasc Surg (Torino). 1999 Apr;40(2):197-201.
This study was planned to show the effect of retroperfusion and cardiopulmonary bypass on myocardial hemodynamic recovery.
Eighteen dogs entered this study. After, left anterior descending artery (LAD) was dissected and occluded, the animals were divided into three equal groups; Group I: retrograde coronary sinus perfusion, group II: cardiopulmonary bypass and retrograde coronary sinus perfusion, Group III: control group, left anterior descending artery occlusion only.
In Group III, deterioration of the hemodynamic values progressed parallel with the degree of ischemic damage but in Group I, hemodynamic parameters were better because of the retrograde coronary sinus perfusion and minimally affected by the reperfusion. In Group II, at the end of the cardiopulmonary bypass minimal myocardial damage was observed.
There is no statistical difference between Group I and II if we examine the data that was taken after reperfusion although myocardial performance was better in Group II.
本研究旨在显示逆行灌注和体外循环对心肌血流动力学恢复的影响。
18只犬进入本研究。在解剖并阻断左前降支动脉（LAD）后，将动物分为三组，每组数量相等；第一组：逆行冠状窦灌注；第二组：体外循环和逆行冠状窦灌注；第三组：对照组，仅阻断左前降支动脉。
在第三组中，血流动力学值的恶化与缺血损伤程度平行进展，但在第一组中，由于逆行冠状窦灌注，血流动力学参数较好，且受再灌注的影响最小。在第二组中，体外循环结束时观察到最小程度的心肌损伤。
尽管第二组的心肌性能较好，但如果我们检查再灌注后采集的数据，第一组和第二组之间没有统计学差异。
