Fu X P, Zhang K J, Ye S D, Dong N G, Shao Y M, Xu Z J, Lan H J
Department of Cardiovascular Surgery, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1993;13(1):45-50. doi: 10.1007/BF02886594.
The present study was undertaken to evaluate the improved protection of antegrade aortic root perfusion combined with intermittent coronary sinus occlusion (APCSO) for the 1-hour ischemic myocardium in the presence of left anterior descending artery occlusion, 12 dogs were divided into 2 groups: anteperfusion (AP) alone (n = 6) and APCSO (n = 6). The experimental results showed that APCSO provided a better cardioplegic distribution and a lower hypothermia (15.6 degrees C versus 17.2 degrees C) in the occluded LAD region, compared with AP. After ischemia, cardiac index and left ventricular stroke index recovered excellently in APCSO (128% to 141% and 115% to 158% of preischemic values, respectively), and much worse in AP (69% to 82% and 53% to 73% of preischemic values, respectively). Our study has confirmed that APCSO is superior to AP in myocardial protection in the presence of coronary artery occlusion.
本研究旨在评估在左前降支动脉闭塞情况下，顺行性主动脉根部灌注联合间歇性冠状静脉窦闭塞（APCSO）对1小时缺血心肌的改良保护作用。将12只犬分为2组：单纯顺行灌注（AP）组（n = 6）和APCSO组（n = 6）。实验结果表明，与AP相比，APCSO在闭塞的左前降支区域提供了更好的心脏停搏分布和更低的体温（15.6摄氏度对17.2摄氏度）。缺血后，APCSO组的心脏指数和左心室搏出指数恢复良好（分别为缺血前值的128%至141%和115%至158%），而AP组则差得多（分别为缺血前值的69%至82%和53%至73%）。我们的研究证实，在冠状动脉闭塞的情况下，APCSO在心肌保护方面优于AP。
