Niemeier R W
Environ Health Perspect. 1976 Aug;16:67-71. doi: 10.1289/ehp.761667.
The isolated perfused lung (IPL), when compared to available in vitro and in vivo pulmonary systems, is a preparation that fulfills a majority of the ideal criteria for studying metabolism, binding and/or physiological response to xenobiotics. The IPL is an exceptionally useful method when there is a need for concurrent administration of multiple agents in different physical forms. Various details such as physiological and biochemical parameters and the construction of a small animal tracheal valve system are discussed.
与现有的体外和体内肺部系统相比，离体灌注肺（IPL）是一种能满足研究异生物代谢、结合和/或生理反应的大多数理想标准的制备方法。当需要同时给予多种不同物理形式的药物时，IPL是一种特别有用的方法。文中讨论了各种细节，如生理和生化参数以及小动物气管瓣膜系统的构建。
