Tomizuka H, Hatake K, Kitagawa S, Yamashita K, Arai H, Miura Y
Division of Haematology, Department of Internal Medicine, Institute of Haematology, Jichi Medical School, Tochigi, Japan.
Acta Haematol. 1999;101(3):149-52. doi: 10.1159/000040942.
A 28-year-old man was hospitalized with nausea, vomiting, abdominal pain and low-grade fever. He had a 6-month history of paroxysmal nocturnal haemoglobinuria (PNH), and laboratory data showed anaemia and liver dysfunction. An abdominal ultrasonography showed ascites and portal vein thrombosis. After receiving antithrombotic treatment, the portal vein thrombosis did not extend. Portal vein thrombosis is very rare but should be considered when we encounter liver dysfunction associated with PNH as well as hepatic vein thrombosis. Ultrasonography is very useful in detecting portal vein thrombosis and facilitating early diagnosis. Warfarin is very effective in preventing exacerbation of portal vein thrombosis in PNH.
一名28岁男性因恶心、呕吐、腹痛和低热入院。他有阵发性夜间血红蛋白尿（PNH）6个月病史，实验室检查显示贫血和肝功能障碍。腹部超声显示腹水和门静脉血栓形成。接受抗血栓治疗后，门静脉血栓未进展。门静脉血栓形成非常罕见，但当我们遇到与PNH相关的肝功能障碍以及肝静脉血栓形成时应予以考虑。超声在检测门静脉血栓形成和促进早期诊断方面非常有用。华法林在预防PNH患者门静脉血栓形成加重方面非常有效。
