印度人群中的人类特异性插入/缺失多态性及其可能的进化意义。

Human-specific insertion/deletion polymorphisms in Indian populations and their possible evolutionary implications.

作者信息

Majumder P P, Roy B, Banerjee S, Chakraborty M, Dey B, Mukherjee N, Roy M, Thakurta P G, Sil S K

机构信息

Anthropology and Human Genetics Unit, Indian Statistical Institute, Calcutta, India.

出版信息

Eur J Hum Genet. 1999 May-Jun;7(4):435-46. doi: 10.1038/sj.ejhg.5200317.

DOI:10.1038/sj.ejhg.5200317

PMID:10352934

Abstract

DNA samples from 396 unrelated individuals belonging to 14 ethnic populations of India, inhabiting various geographical locations and occupying various positions in the socio-cultural hierarchy, were analysed in respect of 8 human-specific polymorphic insertion/deletion loci. All loci, except Alu CD4, were found to be highly polymorphic in all populations. The levels of average heterozygosities were found to be very high in all populations and, in most populations, also higher than those predicted by the island model of population structure. The coefficient of gene differentiation among Indian populations was found to be higher than populations in most other global regions, except Africa. These results are discussed in the light of two possible scenarios of evolution of Indian populations in the broader context of human evolution.

摘要

对来自印度14个民族的396名无亲缘关系个体的DNA样本进行了分析，这些个体居住在不同地理位置，在社会文化等级制度中占据不同地位，分析涉及8个人类特异性多态插入/缺失位点。除Alu CD4外，所有位点在所有群体中均发现具有高度多态性。发现所有群体的平均杂合度水平都非常高，并且在大多数群体中，也高于群体结构岛屿模型预测的水平。除非洲外，发现印度群体之间的基因分化系数高于大多数其他全球区域的群体。在人类进化的更广泛背景下，根据印度群体进化的两种可能情况对这些结果进行了讨论。