Yip Jia Qi, Oo Adrian, Ng Yan Ling, Chin Kim Ling, Tan Kim-Kee, Chu Justin Jang Hann, AbuBakar Sazaly, Zainal Nurhafiza
Tropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Institute for Advanced Studies, Advanced Studies Complex, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Virol J. 2024 Dec 20;21(1):327. doi: 10.1186/s12985-024-02597-3.
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over the past three years. One critical aspect of the disease is the intricate interplay between the virus and the host immune response, particularly the role of inflammatory gene expression in severe COVID-19. While numerous previous studies have explored the role of genetic polymorphisms in COVID-19, research specifically focusing on inflammatory genes and their associations with disease severity remains limited. This review explores the relationship between severe COVID-19 outcomes and genetic polymorphisms within key inflammatory genes. By investigating the impact of genetic variations on immune responses, which include cytokine production and downstream signalling pathways, we aim to provide a comprehensive overview of how genetic polymorphisms contribute to the variability in disease presentation. Through an in-depth analysis of existing literature, we shed light on potential therapeutic targets and personalized approaches that may enhance our understanding of disease pathogenesis and treatment strategies.
由新型冠状病毒SARS-CoV-2引起的新冠疫情在过去三年里对全球医疗系统产生了深远影响，并激发了广泛的研究工作。该疾病的一个关键方面是病毒与宿主免疫反应之间的复杂相互作用，特别是炎症基因表达在重症新冠中的作用。虽然此前有许多研究探讨了基因多态性在新冠中的作用，但专门针对炎症基因及其与疾病严重程度关联的研究仍然有限。本综述探讨了重症新冠结局与关键炎症基因内基因多态性之间的关系。通过研究基因变异对免疫反应的影响，包括细胞因子产生和下游信号通路，我们旨在全面概述基因多态性如何导致疾病表现的变异性。通过对现有文献的深入分析，我们揭示了可能增强我们对疾病发病机制和治疗策略理解的潜在治疗靶点和个性化方法。
