Redecker P
Medizinische Hochschule Hannover, Abt. Anatomie 1, Germany.
Neurosci Lett. 1999 May 7;266(2):117-20. doi: 10.1016/s0304-3940(99)00268-2.
In order to further elucidate the role of gamma-aminobutyric acid (GABA) within the mammalian pineal gland, an immunocytochemical study was performed aimed at providing information on the occurrence and localization of the plasma-lemmal GABA transporters GAT-1-3 in the gerbil pineal organ. Whereas all three transporter subtypes were regularly present in this endocrine tissue, their cellular distribution differed. The analysis of serial semi-thin sections showed that pinealocytes as well as interstitial glial cells contain immunocytochemically detectable amounts of GAT proteins, indicating that both pineal parenchymal cell types participate in GABA reuptake. These results lend additional support to the hypothesis that GABA serves important physiological functions in the pineal gland.
为了进一步阐明γ-氨基丁酸（GABA）在哺乳动物松果体内的作用，进行了一项免疫细胞化学研究，旨在提供有关沙鼠松果体器官中质膜GABA转运体GAT-1至GAT-3的存在和定位信息。尽管所有三种转运体亚型都正常存在于这种内分泌组织中，但它们的细胞分布有所不同。对连续半薄切片的分析表明，松果体细胞以及间质神经胶质细胞含有免疫细胞化学可检测量的GAT蛋白，这表明两种松果实质细胞类型都参与了GABA的再摄取。这些结果为GABA在松果体中发挥重要生理功能的假说提供了更多支持。
