Langlet C, Canu M H, Falempin M
Laboratoire de Plasticité Neuromusculaire, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
Neurosci Lett. 1999 May 7;266(2):145-8. doi: 10.1016/s0304-3940(99)00296-7.
This study was performed to determine if hypodynamia-hypokinesia (HH) could induce a reorganization of the rat somatosensory cortex. The cortical hindpaw representation was determined by stimulating the limb and recording multi-unit cortical activity. The size of the cutaneous receptive fields was also measured. After 14 days of HH, the size of the cortical hindpaw representation was decreased. The proportion of small cutaneous receptive fields decreased while the large ones increased. After 7 days of HH, no change in the two studied parameters was noticed in five animals. In the other rats, a number of sites unresponsive to cutaneous stimulation or with high thresholds was observed. This study provides evidence of a plasticity of the somatosensory cortex induced by a situation that reduces both sensory and motor functions. The cortical reorganization occurs in two stages.
本研究旨在确定动力不足-运动功能减退（HH）是否会引起大鼠体感皮层的重组。通过刺激肢体并记录多单位皮层活动来确定皮层后爪代表区。还测量了皮肤感受野的大小。HH持续14天后，皮层后爪代表区的大小减小。小皮肤感受野的比例下降，而大皮肤感受野的比例增加。HH持续7天后，五只动物的这两个研究参数未发现变化。在其他大鼠中，观察到一些对皮肤刺激无反应或阈值较高的部位。本研究提供了证据，证明由同时降低感觉和运动功能的情况所诱导的体感皮层可塑性。皮层重组分两个阶段发生。
