肿瘤大小：嗜铬细胞瘤和副神经节瘤中¹³¹I MIBG摄取的唯一预测因素。

Tumour size: the only predictive factor for 131I MIBG uptake in phaeochromocytoma and paraganglioma.

作者信息

Nguyen H H, Proye C A, Carnaille B, Combemale F, Pattou F N, Huglo D

机构信息

Department of General and Endocrine Surgery, Hôpital Claude-Huriez, Lille, France.

出版信息

Aust N Z J Surg. 1999 May;69(5):350-3. doi: 10.1046/j.1440-1622.1999.01570.x.

DOI:10.1046/j.1440-1622.1999.01570.x

PMID:10353549

Abstract

BACKGROUND

131I Meta-iodobenzylguanidine (131I MIBG) scintigraphy can detect chromaffin tumours with a high specificity but its sensitivity remains limited. In this study, the influence of clinical features and tumour pathology on the results of 131I MIBG of patients with phaeochromocytomas and paragangliomas was examined.

METHODS

The records of 104 patients operated on for chromaffin tumours who had pre-operative 131I MIBG were reviewed. Demographic data, clinical features, biochemical results and pathology of tumours were analysed. The size of the tumour was assessed by the three measured diameters of the specimen and its calculated volume. Univariate relationship between tumours' characteristics and the results of 131I MIBG were examined.

RESULTS

Out of 119 tumours, 104 (87%) were detected by 131I MIBG. Mean +/- SD largest diameter and volume of the tumours were 6.0 +/- 2.4 cm (range 0.8-11.5 cm) and 68 +/- 74 cm3 (range 0.2-421 cm3). Results of 131I MIBG were significantly correlated with both the largest diameter of the tumour (P < 0.01) and by its volume (P < 0.001). 131I MIBG was negative in 35.5% of tumours < 20 cm3 and in 2.6% of those < 20 cm3. No other criteria were correlated with positive 131I MIBG, including aetiology, pathology or catecholamine secretion pattern.

CONCLUSIONS

The result of 131I MIBG scanning in patients with chromaffin tumours is significantly correlated with the size of the tumour.

摘要

背景

131I间碘苄胍（131I MIBG）闪烁扫描术能够高特异性地检测嗜铬细胞瘤，但其敏感性仍然有限。在本研究中，调查了临床特征和肿瘤病理对嗜铬细胞瘤和副神经节瘤患者131I MIBG结果的影响。

方法

回顾了104例接受嗜铬细胞瘤手术且术前行131I MIBG检查患者的记录。分析了人口统计学数据、临床特征、生化结果和肿瘤病理。通过标本的三个测量直径及其计算体积评估肿瘤大小。检查肿瘤特征与131I MIBG结果之间的单变量关系。

结果

在119个肿瘤中，104个（87%）通过131I MIBG检测到。肿瘤的平均±标准差最大直径和体积分别为6.0±2.4 cm（范围0.8 - 11.5 cm）和68±74 cm³（范围0.2 - 421 cm³）。131I MIBG结果与肿瘤的最大直径（P < 0.01）及其体积（P < 0.001）均显著相关。在体积<20 cm³的肿瘤中，35.5%的131I MIBG为阴性，在体积<20 cm³的肿瘤中，这一比例为2.6%。没有其他标准与131I MIBG阳性相关，包括病因、病理或儿茶酚胺分泌模式。