Rongioletti F, Ghio L, Ginevri F, Bleidl D, Rinaldi S, Edefonti A, Gambini C, Rizzoni G, Rebora A
DISEM, Section of Dermatology, University of Genoa, Italy.
Br J Dermatol. 1999 May;140(5):948-51. doi: 10.1046/j.1365-2133.1999.02833.x.
The cutaneous side-effects of levamisole include non-specific and lichenoid eruptions, fixed drug eruption and, very rarely, cutaneous vasculitis. We describe a distinctive clinical and histological vasculopathy with immunological abnormalities in children with paediatric nephrotic syndrome receiving long-term levamisole treatment. Four boys and one girl were identified. Their average age was 10 years. Levamisole had been used for an average of 24 months. Purpura of the ears was the most common finding corresponding histologically to a vasculopathic reaction pattern ranging from a leucocytoclastic and thrombotic vasculitis to a vascular occlusive disease without true vasculitis but with associated antinuclear, antiphospholipid and anticytoplasmic antibodies. The eruption resolved in all patients 2-3 weeks after the discontinuation of levamisole, but serum autoantibodies persisted for 2-14 months.
左旋咪唑的皮肤副作用包括非特异性和苔藓样皮疹、固定性药疹，以及极为罕见的皮肤血管炎。我们描述了在接受长期左旋咪唑治疗的小儿肾病综合征患儿中出现的一种具有独特临床和组织学表现的血管病变，并伴有免疫异常。共确定了4名男孩和1名女孩。他们的平均年龄为10岁。左旋咪唑的平均使用时间为24个月。耳部紫癜是最常见的表现，组织学上对应的血管病变反应模式范围从白细胞破碎性和血栓性血管炎到无真正血管炎但伴有抗核抗体、抗磷脂抗体和抗细胞质抗体的血管闭塞性疾病。所有患者在停用左旋咪唑后2 - 3周皮疹消退，但血清自身抗体持续存在2 - 14个月。
